Denosumab

BUS 690 Case #2: Forecasting Denosumab Amgen was maven of the humanitys leading biotechnology companies, with more than 17,000 employees and almost $15 billion in revenue. Amgens most important drugs furnish in: * Aranesp-anemia; declining sharply * Epogen-anemia * Enbrel-arthritis * Neulasta-febrile neutropenia, a condition associated with chemotherapy Amgen has developed a new yield called Denosumab under brand names Prolia and Xgeva, and had patents that were plan to expire betwixt 2017 and 2023. Prolia treats Osteoporosis, a osseous tissue disorder, common exactly serious condition. Xgeva seeks to go along skeletal-related events from occurring in cancer patients with bone metastases. Prolia Osteoporosis is diagnosed by BMDbone mineral density mental test, the unproblematic BMD test was dual-energy X-ray absorptiometry (DXA); a BMD test costs $50 per patient. Amgen priced Prolia at $825 per injection, or $1,650 per year. There is a total of 30.7 one thousand meg people in the U.S. with osteoporosis or osteopenia, and 15.5 million (49%) were diagnosed, only a portion of that group received intervention. 40% of patients receiving interference continued to see declining BMD levels, and 5% had fractures.

Aside from interference options of exercise and dietary supplements, bisphosphonates are the main class of drugs for the discussion of osteopenia and osteoporosis in early 2011, made from two phosphonic groups. The drugs worked by deceleration the breakdown of bone by osteoclasts, resulting in an increase in BMD and a decrease i n fractures. Despite the strong ingenuit! y of bisphosphonates, compliance was low; studies indicated that about 50% of patients discontinued ad-lib examination bisphosphonate therapy within the first year. Prolias competition: | U.S. sales (mil) | division| Boniva| $600.00 | 2008| Reclast| $579.00 | 2010| Evista| $682.00 | 2009| Forteo| $518.00 | 2009| Total U.S. sales of competitors:| $2,379.00 | | Prolia is administered by...If you want to get a well(p) essay, order it on our website: OrderCustomPaper.com

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